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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 8.79
Human Site: S1005 Identified Species: 17.58
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 S1005 T P S N D G K S K D K P P K R
Chimpanzee Pan troglodytes XP_001172395 1581 168474 S1005 T P S N D G K S K D K P P K R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 D1007 S N D G K S K D K P P K R K K
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 D1007 S N D G K S K D K P P K R K K
Rat Rattus norvegicus NP_001127833 1567 166392 K991 P S N D G K S K D K P P K R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589
Chicken Gallus gallus XP_418125 1594 169410 E1016 S S D G K S K E K L P K R K K
Frog Xenopus laevis Q6INP8 1570 165663 D996 S S D G K S K D K P P K R K K
Zebra Danio Brachydanio rerio XP_700209 1694 176982 S1063 T P S S E G K S K D K P A K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 G928 S G P S A S S G S S G A T G L
Honey Bee Apis mellifera XP_395879 1811 193227 H1231 G N S S P K T H T G L K P G V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 Q1451 K S L S T P T Q S P N S S K A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 20 N.A. 20 6.6 N.A. 0 20 20 80 N.A. 0 13.3 N.A. 6.6
P-Site Similarity: 100 100 N.A. 33.3 N.A. 33.3 33.3 N.A. 0 33.3 33.3 93.3 N.A. 13.3 20 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 0 0 0 9 9 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 34 9 17 0 0 25 9 25 0 0 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 9 0 34 9 25 0 9 0 9 9 0 0 17 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 0 0 34 17 59 9 59 9 25 42 9 67 42 % K
% Leu: 0 0 9 0 0 0 0 0 0 9 9 0 0 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 25 9 17 0 0 0 0 0 0 9 0 0 0 0 % N
% Pro: 9 25 9 0 9 9 0 0 0 34 42 34 25 0 0 % P
% Gln: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 34 9 25 % R
% Ser: 42 34 34 34 0 42 17 25 17 9 0 9 9 0 0 % S
% Thr: 25 0 0 0 9 0 17 0 9 0 0 0 9 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _